Hemoglobin A1c

In cases of rapidly evolving Type 1 diabetes, the increase of HbA1c values might be delayed compared to the acute increase in glucose concentrations. In these conditions, diabetes mellitus must be diagnosed based on plasma glucose concentration and/or the typical clinical symptoms.

The CAPI 3 Hb A1c kit should not be used:
-in monitoring daily glucose control,
-to replace daily home testing of urine and blood glucose levels,
-to replace glucose testing in pediatric patients, pregnant women, or patients with Type 1 diabetes,
- for analyzing samples from patients with total hemoglobin level of less than 2.9 or greater than 30.5 g/dL and any hemoglobinopathies that may interfere,
-to diagnose diabeted during pregnancy or to diagnose gestational diabetes. HbA1c reflects the average blood glucose levels over the preceding 3 months ( the average life of a red blood cell), and therefore may be falsely low during pregnancy or any other condition associated with recent onset of hyperglycemia and/pr decreased red cell survival,
-to diagnose diabetes in patients with the following conditions:
-Any condition that alters the life span of the red blood cells, including recent blood loss, transfusion, significant irony deficiency, hemolytic anemia ( including hereditary spherocytosis) or other hemolytic diseases, hemoglobinopathies and thalassemias, as the altered red blood cell turnover interferes with the relationship between mean blood glucose and HbA1c values,
-Malignancies or server chronic hepatic and renal disease.