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Gastrointestinal Pathogen Panel (GPP)

Alternate Name: GPP_ABC

  | GPP

SAL Code:

2200

CPT:

87507

Loinc:

82195-9

Turn Around Time:

48h-72h

Setup:

Daily

Department:

Gastrointestinal Pathogen Panel

Performing Laboratory:

Sherman Abrams Laboratory

Methodology:

PCR

Specimen Requirements:

Primary Tube:

Cary Blair

Primary Substance:

Stool

Temperature

Period

Stable Ambient:

4 Days

Stable Fridge:

4 Days

Rejection Criteria:

Reject specimens that are improperly identified, leaking/compromised, or of insufficient quantity (less than fill line). Specimens collected in any container/transport medium that is not Cary-Blair or fecal swabs, and/or transported/stored outside the manufacturer-established stability requirements will also be rejected. Frozen specimens and formed stool are unacceptable for reporting C. difficile.

Additional Information:

The BioCode Gastrointestinal Pathogen Panel (GPP) is indicated for patients presenting with signs and symptoms of acute, severe, or persistent gastroenteritis, such as severe diarrhea, abdominal cramps, fever, or bloody stool. Because bacterial, viral, and parasitic GI infections present with overlapping clinical symptoms, this multiplex molecular test is ordered to provide a rapid, definitive differential diagnosis that traditional culture methods cannot achieve quickly. Clinicians utilize these rapid results to identify highly contagious pathogens, implement immediate infection control measures, avoid inappropriate empirical antibiotic therapy (which can be contraindicated in certain infections like STEC), and initiate targeted, pathogen-specific patient management.

Test Limitations:

A negative result does not exclude infectious gastroenteritis, as the causative organism may be a pathogen not targeted by this 17-target assay, or present at levels below the limit of detection. Conversely, because this molecular test detects non-viable microbial DNA/RNA, a positive result may indicate asymptomatic colonization, persistent nucleic acid shedding from a prior illness, or a non-pathogenic presence rather than active, disease-producing infection. Results must be interpreted alongside the patient's complete clinical history, epidemiological data, and other laboratory findings; non-infectious etiologies (e.g., IBD or IBS) should be considered in symptomatic patients who test negative.

Test Information:

Components:

Component Name CPT Loinc
Adenovirus 40/41 92690-7
Campylobacter spp. 105640-7
Clostridium difficile (Toxin A/B) 87493 105883-3
Cryptosporidium spp. 92688-1
E. coli O157 97320-6
Entamoeba histolytica 92689-9
Enteroaggregative E. coli (EAEC) 97317-2
Enterotoxigenic E. coli (ETEC) 97319-8
Giardia lamblia 92687-3
Norovirus (GI/GII) 92692-3
Rotavirus A 92693-1
Salmonella spp. 105913-8
Shiga toxin producing E. coli (STEC) 80679-4
Shigella/Enteroinvasive E. coli (EIEC) 70243-3
Vibrio parahaemolyticus 97315-6
Vibrio spp. (not parahaemolyticus) 92686-5
Yersinia enterocolitica 92723-6